Publications in biomedical fields
by Paul J. Lewi

Back to Home Page

1:     Njai HF, Lewi PJ, Janssen CG, Garcia S, Fransen K, Kestens L, Vanham G,Janssen PA.
Pre-incubation of cell-free HIV-1 group M isolates with non-nucleoside reverse transcriptase inhibitors blocks subsequent viral replication in co-cultures of dendritic cells and T cells.
Antivir Ther. 2005;10(2):255-62.

2:    de Jonge MR, Koymans LM, Vinkers HM, Daeyaert FF, Heeres J, Lewi PJ, Janssen PA.
Structure based activity prediction of HIV-1 reverse transcriptase inhibitors.
J Med Chem. 2005 Mar 24;48(6):2176-83.

3:    Guillemont J, Pasquier E, Palandjian P, Vernier D, Gaurrand S, Lewi PJ,Heeres J, de Jonge MR, Koymans LM, Daeyaert FF, VinkersMH,ArnoldE, Das K, Pauwels R, Andries K, de Bethune MP, Bettens E, Hertogs K, Wigerinck P, Timmerman P, Janssen PA.
Synthesis of novel diarylpyrimidine analogues and their antiviral activity
against human immunodeficiency virus type 1.
J Med Chem. 2005 Mar 24;48(6):2072-9.

4:    Frenkel YV, Clark AD Jr, Das K, Wang YH, Lewi PJ, Janssen PA, Arnold E.
Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability.
J Med Chem. 2005 Mar 24;48(6):1974-83.

5:     Heeres J, de Jonge MR, Koymans LM, Daeyaert FF, Vinkers M, Van Aken KJ, Arnold E, Das K, Kilonda A, Hoornaert GJ, Compernolle F, Cegla M, Azzam RA, Andries K, de Bethune MP, Azijn H, Pauwels R, Lewi PJ, Janssen PA.
Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside
HIV-1 reverse transcriptase inhibitory activity.
J Med Chem. 2005 Mar 24;48(6):1910-8.

6:     Janssen PA, Lewi PJ, Arnold E, Daeyaert F, de Jonge M, Heeres J, Koymans L, Vinkers M, Guillemont J, Pasquier E, Kukla M, Ludovici D, Andries K, de Bethune MP, Pauwels R, Das K, Clark AD Jr, Frenkel YV, Hughes SH, Medaer B, De Knaep F, Bohets H, De Clerck F, Lampo A, Williams P, Stoffels P.
In search of a novel anti-HIV drug: multidisciplinary coordination in thediscovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).
J Med Chem. 2005 Mar 24;48(6):1901-9. Review.

7:    Das K,Lewi PJ, Hughes SH, Arnold E.
Crystallography and the design of anti-AIDS drugs: conformational flexibilityand positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors.
Prog Biophys Mol Biol. 2005 Jun;88(2):209-31. Review.

8:    Van Herrewege Y, Vanham G, Michiels J, Fransen K, Kestens L, Andries K, Janssen P, Lewi P.
A series of diaryltriazines and diarylpyrimidines are highly potent nonnucleoside reverse transcriptase inhibitors with possible applications as microbicides.
Antimicrob Agents Chemother. 2004 Oct;48(10):3684-9.

9:     Lewi P, Arnold E, Andries K, Bohets H, Borghys H, Clark A, Daeyaert F, DasK, de Bethune MP, de Jonge M, Heeres J, Koymans L, Leempoels J, Peeters J,Timmerman P, Van den Broeck W, Vanhoutte F, Van't Klooster G, Vinkers M, Volovik Y, Janssen PA.

Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds.
Drugs R D. 2004;5(5):245-57.

10:    Das K, Clark AD Jr, Lewi PJ, Heeres J, De Jonge MR, Koymans LM, Vinkers HM, Daeyaert F, Ludovici DW, Kukla MJ, De Corte B, Kavash RW, Ho CY, Ye H, Lichtenstein MA, Andries K, Pauwels R, De Bethune MP, Boyer PL, Clark P, Hughes SH, Janssen PA, Arnold E.
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitorsthat are highly potent and effective against wild-type and drug-resistant HIV-1 variants.
J Med Chem. 2004 May 6;47(10):2550-60.

11:    Lewi P.
Obituary of Dr Paul Janssen (1926-2003).
Drug Discov Today. 2004 May 15;9(10):432-3.

12:    Daszykowski M, Walczak B, Xu QS, Daeyaert F, de Jonge MR, Heeres J, Koymans LM, Lewi PJ, Vinkers HM, Janssen PA, Massart DL.
Classification and regression trees--studies of HIV reverse transcriptase inhibitors.
J Chem Inf Comput Sci. 2004 Mar-Apr;44(2):716-26.

13:    Wouters L, Gohlmann HW, Bijnens L, Kass SU, Molenberghs G, Lewi PJ.
Graphical exploration of gene expression data: a comparative study of three multivariate methods.
Biometrics. 2003 Dec;59(4):1131-9.

14:    Daeyaert F, de Jonge M, Heeres J, Koymans L, Lewi P, Vinkers MH, Janssen PA.
A pharmacophore docking algorithm and its application to the cross-docking of 18 HIV-NNRTI's in their binding pockets.
Proteins. 2004 Feb 15;54(3):526-33.

15:    Vinkers HM, de Jonge MR, Daeyaert ED, Heeres J, Koymans LM, van Lenthe JH, Lewi PJ, Timmerman H, Janssen PA.
Inhibition and substrate recognition--a computational approach applied to HIV protease.
J Comput Aided Mol Des. 2003 Sep;17(9):567-81.

16:     Van Herrewege Y, Michiels J, Van Roey J, Fransen K, Kestens L, Balzarini J, Lewi P, Vanham G, Janssen P.
In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides.
Antimicrob Agents Chemother. 2004 Jan;48(1):337-9.

17:     Lisitsa A, Archakov A, Lewi P, Janssen P.
Bioinformatic insight into the unity and diversity of cytochromes P450.
Methods Find Exp Clin Pharmacol. 2003 Nov;25(9):733-45. Review.

18:    Lewi PJ, de Jonge M, Daeyaert F, Koymans L, Vinkers M, Heeres J, Janssen PA, Arnold E, Das K, Clark AD Jr, Hughes SH, Boyer PL, de Bethune MP, Pauwels R, Andries K, Kukla M, Ludovici D, De Corte B, Kavash R, Ho C.
On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data.
J Comput Aided Mol Des. 2003 Feb-Apr;17(2-4):129-34.
Erratum in: J Comput Aided Mol Des. 2003 May-Jun;17(5-6):398. Lewis PJ [corrected to Lewi PJ].

19: VVinkers HM, de Jonge MR, Daeyaert FF, Heeres J, Koymans LM, van Lenthe JH, Lewi PJ, Timmerman H, Van Aken K, Janssen PA.
SYNOPSIS: SYNthesize and OPtimize System in Silico.
J Med Chem. 2003 Jun 19;46(13):2765-73.

20:    Archakov AI, Govorun VM, Dubanov AV, Ivanov YD, Veselovsky AV, Lewi P, Janssen P.
Protein-protein interactions as a target for drugs in proteomics.
Proteomics. 2003 Apr;3(4):380-91. Review.

21:    Veselovsky AV, Ivanov YD, Ivanov AS, Archakov AI, Lewi P, Janssen P.
Protein-protein interactions: mechanisms and modification by drugs.
J Mol Recognit. 2002 Nov-Dec;15(6):405-22. Review.

22:    Ludovici DW, De Corte BL, Kukla MJ, Ye H, Ho CY, Lichtenstein MA, Kavash RW, Andries K, de Bethune MP, Azijn H, Pauwels R, Lewi PJ, Heeres J, Koymans LM, de Jonge MR, Van Aken KJ, Daeyaert FF, Das K, Arnold E, Janssen PA.
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.
Bioorg Med Chem Lett. 2001 Sep 3;11(17):2235-9.

23:    Ludovici DW, Kavash RW, Kukla MJ, Ho CY, Ye H, De Corte BL, Andries K, de Bethune MP, Azijn H, Pauwels R, Moereels HE, Heeres J, Koymans LM, de Jonge MR, Van Aken KJ, Daeyaert FF, Lewi PJ, Das K, Arnold E, Janssen PA.
Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues.
Bioorg Med Chem Lett. 2001 Sep 3;11(17):2229-34.

24:    Hsiou Y, Ding J, Das K, Clark AD Jr, Boyer PL, Lewi P, Janssen PA, KleimJP, Rosner M, Hughes SH, Arnold E.
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance.
J Mol Biol. 2001 Jun 1;309(2):437-45.

25:    Reijmers TH, Wehrens R, Daeyaert FD,Lewi PJ, Buydens LM.
Using genetic algorithms for the construction of phylogenetic trees: application to G-protein coupled receptor sequences.
Biosystems. 1999 Jan;49(1):31-43.

26:    Daeyaert F, Moereels H, Lewi PJ.
Classification and identification of proteins by means of common and specific amino acid n-tuples in unaligned sequences.
Comput Methods Programs Biomed. 1998 Jun;56(3):221-33.

27:    Moereels H, Lewi PJ, Daeyaert F, Schenck E, Janssen PA.
The alpha and omega of G-protein coupled receptors: a novel method for classification. Part 2. Bin classification.
Receptors Channels. 1997;5(3-4):139-48.

28:    Smith AD, Geisler SC, Chen AA, Resnick DA, Roy BM, Lewi PJ, Arnold E, Arnold GF.
Human rhinovirus type 14:human immunodeficiency virus type 1 (HIV-1) V3 loop chimeras from a combinatorial library induce potent neutralizing antibody responses against HIV-1.
J Virol. 1998 Jan;72(1):651-9.

29:     Moereels H, Lewi PJ, Koymans LM, Janssen PA.
The alpha and omega of G protein-coupled receptors. A novel method for classification.
Ann N Y Acad Sci. 1997 May 30;812:147-8. Review.

30:    Nyambi PN, Lewi P, Peeters M, Janssens W, Heyndrickx L, Fransen K, Andries K, Vanden Haesevelde M, Heeney J, Piot P, van der Groen G.
Study of the dynamics of neutralization escape mutants in a chimpanzee naturally infected with the simian immunodeficiency virus SIVcpz-ant.
J Virol. 1997 Mar;71(3):2320-30.

31:    Nyambi PN, Nkengasong J, Lewi P, Andries K, Janssens W, Fransen K,Heyndrickx L, Piot P, van der Groen G.
Multivariate analysis of human immunodeficiency virus type 1 neutralization data.
J Virol. 1996 Sep;70(9):6235-43.

32:    Odds FC, Dams G, Just G, Lewi P.
Susceptibilities of Candida spp. to antifungal agents visualized by two-dimensional scatterplots of relative growth.
Antimicrob Agents Chemother. 1996 Mar;40(3):588-94.

33:    Moereels H, Lewi PJ, Koymans LM, Janssen PA.
The alpha and omega of G-protein coupled receptors: a novel method for classification. Part 1.
Receptors Channels. 1996;4(1):19-30.

34:    Martens P, Calle P, Hubloue I, Van den Poel B, Lewi P.
Does age have an effect on the time of occurrence of cardiac arrest of presumed cardiac etiology?
Belgian Cardiopulmonary-Cerebral Resuscitation Study Group.
Cardiology. 1995;86(3):197-201.

35:     Martens PR, Calle P, Van den Poel B, Lewi P.
Further prospective evidence of a circadian variation in the frequency of call for sudden cardiac death.
Belgian Cardiopulmonary Cerebral Resuscitation Study Group.
Intensive Care Med. 1995 Jan;21(1):45-9.

36:    Andries K, Dewindt B, Snoeks J, Willebrords R, Stokbroekx R, Lewi PJ.
A comparative test of fifteen compounds against all known human rhinovirus serotypes as a basis for a more rational screening program.
Antiviral Res. 1991 Oct;16(3):213-25.

37:    Andries K, Dewindt B, Snoeks J, Wouters L, Moereels H, Lewi PJ, Janssen PA.
Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity.
J Virol. 1990 Mar;64(3):1117-23.

38:    Janssen PA, Janssen H, Cauwenbergh G, De Doncker P, De Beule K, Lewi P, Tytgat HF, Lapiere CM.
Use of topical ketanserin in the treatment of skin ulcers: a double-blind study.
J Am Acad Dermatol. 1989 Jul;21(1):85-90.

39:    Lewi PJ, Mullie A, Quets A.
Relevance and significance of pre-CPR conditions in cardio-pulmonary-cerebral resuscitation. A graphic analysis by means of Spectramap.
The Cerebral Resuscitation Study Group.
Resuscitation. 1989;17 Suppl:S35-44; discussion S199-206.

40:    Delooz HH, Lewi PJ.
Are inter-center differences in EMS-management and sodium-bicarbonate administration important for the outcome of CPR?
The Cerebral Resuscitation Study Group.
Resuscitation. 1989;17 Suppl:S161-72; discussion S199-206.

41:    Delooz HH, Lewi PJ.
Early prognostic indices after cardiopulmonary resuscitation (CPR). The Cerebral Resuscitation Study Group.
Resuscitation. 1989;17 Suppl:S149-55; discussion S199-206.

42:    Mullie A, Lewi P, Van Hoeyweghen R.
Pre-CPR conditions and the final outcome of CPR.
The Cerebral Resuscitation Study Group.
Resuscitation. 1989;17 Suppl:S11-21; discussion S199-206.

43:    Flameng W, Wouters L, Sergeant P, Lewi P, Borgers M, Thone F, Suy R.
Multivariate analysis of angiographic, histologic, and electrocardiographic data in patients with coronary heart disease.
Circulation. 1984 Jul;70(1):7-17.

44:    Lewi PJ, Marsboom RP.
Toxicology reference data for the Wistar rat.
Arch Toxicol Suppl. 1982;5:271-6.

45:    Lewi PJ.
Multidimensional analysis of pharmacological data.
Rev Pure Appl Pharmacol Sci. 1981 Jul-Sep;2(3):229-90.

46:    Lewi PJ Gervais S, De Laet C, Vandesteene R, Marsboom R.
A comparison between manual and semiautomatic white cell differentiation.
Am J Med Technol. 1980 May;46(5):294-7.
47:    Lewi PJ.
Classification of dopamine-antagonists from pharmacological data.
Life Sci. 1978 Aug 7;23(5):519-21.

48:    Lewi PJ.
The use of multivariate statistics in industrial pharmacology.
Pharmacol Ther [B]. 1978;3(4):481-537. Review.

49:    Symoens J, Lewi PJ.
Degree of responsiveness to levamisole and factors influencing responsiveness and adverse reactions.
J Rheumatol Suppl. 1978;4:26-30.

50:     Lewi PJ, Symoens J.
Levamisole in rheumatoid arthritis--a multivariate analysis of a multicentric study.
J Rheumatol Suppl. 1978;4:17-25.

51:    Lewi PJ, Colpaert FC.
On the classification of antidepressant drugs.
Psychopharmacology (Berl). 1976 Sep 17;49(2):219-24.

52:    Snoeckx LH, Verheyen JL, Van De Water A, Lewi P, Reneman RS.
On-line computation of cardiac output with the thermodilution method, using a digital minicomputer.
Cardiovasc Res. 1976 Sep;10(5):556-64.

53:     Lewi PJ, Heykants JJ, Janssen PA.
Intravenous pharmacokinetic profile in rats of etomidate, a short-acting hypnotic drug.
Arch Int Pharmacodyn Ther. 1976 Mar;220(1):72-85.

54:    Lewi PJ, van Bever WF, Janssen PA.
Classification and discrimination for data analysis in pharmacology.
Eur J Pharmacol. 1976 Feb;35(2):403-7.

55:     Desmedt LK, Niemegeers CJ, Lewi PJ, Janssen PA.
Antagonism of maximal metrazol seizures in rats and its relevance to an experimental classification of antiepileptic drugs.
Arzneimittelforschung. 1976;26(8):1592-603.

56:    Lewi PJ.
Spectral mapping, a technique for classifying biological activity profiles of chemical compounds.
Arzneimittelforschung. 1976;26(7):1295-1300.

57:    Lewi PJ.
Clinical and pharmacological spectral maps of the neuroleptics.
Int Pharmacopsychiatry. 1976;11(3):181-9.

58:    Lewi PJ.
Spectral maps of the Liege-physiognomies of the neuroleptics.
Pharmakopsychiatr Neuropsychopharmakol. 1975 Dec;8(6):375-9.

59:    Lewi PJ, Marsboom R.
Automated weighing procedure for toxicological studies on small animals, using a minicomputer.
Lab Anim Sci. 1975 Aug;25(4):487-90.

60:     Heykants JJ, Meuldermans WE, Michiels LJ, Lewi PJ, Janssen PA
. Distribution, metabolism and excretion of etomidate, a short-acting hypnotic drug, in the rat. Comparative study of (R)-(+)-(--)-Etomidate.
Arch Int Pharmacodyn Ther. 1975 Jul;216(1):113-29.

61:    Lewi PJ.
Pharmacokinetics and Eigenvector decomposition. Two-compartment open system after rapid intravenous administration.
Arch Int Pharmacodyn Ther. 1975 Jun;215(2):283-300.

62:    Lewi PJ, Schaper WK, Gijpen LM.
On the isometric equation of the sarcomere.
Basic Res Cardiol. 1974 Jan-Feb;69(1):21-31.

63:     Flameng W, Schaper W, Lewi P.
Multiple experimental coronary occlusion without infarction. Effects of heart rate and vasodilation.
Am Heart J. 1973 Jun;85(6):767-76.

64:    Lewi PJ, Schaper WK, Van Riel DG, Snoeckx LH, Flameng WJ, Nuyens RF.
The use of a minocomputer in cardiovascular pharmacology.
Arzneimittelforschung. 1973 Mar;23(3):436-41.

65:    Schaper W, Lewi P, Flameng W, Gijpen L.
Myocardial steal produced by coronary vasocilation in chronic coronary artery occlusion.
Basic Res Cardiol. 1973 Jan-Feb;68(1):3-20.

66:    Schaper W, Lewi P, Jageneau A.
Drug effects on cardiac inotropism.
Arch Int Pharmacodyn Ther. 1972 Apr;196:Suppl 196:79-8. Review.

67:    Heykants JJ, Lewi PJ, Janssen PA.
Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 4. Distribution in the rat of diphenoxylate and difenoxine.
Arzneimittelforschung. 1972 Mar;22(3):520-6.

68:    Heykants J, Lewi P, Janssen PA.
On the distribution and metabolism of azaperone (R 1929) in the rat and pig. II. Pharmacokinetics of azaperone in the Wistar rat.
Arzneimittelforschung. 1971 Aug;21(8):1263-9.

69:    Lewi PJ, Braet WW.
Kinetic simulation by digital computer using graphic display techniques.
J Pharm Sci. 1971 Jul;60(7):1079-82.

70:    Schaper W, De Brabander M, Lewi P.
DNA synthesis and mitoses in coronary collateral vessels of the dog.
Circ Res. 1971 Jun;28(6):671-9.

71:     Lewi PJ, Schaper WK, Jageneau AH.
Analysis of the isovolumic pressure in the canine left ventricle.
Pflugers Arch. 1971;329(1):9-22.

72:     Lewi PJ, Schaper WK.
The estimation of coronary volume elasticity in the beating heart of the dog.
Pflugers Arch. 1971;325(3):191-8.

73:     Lewi PJ, Heykants JJ, Janssen PA.
On the distribution and metabolism of neuroleptic drugs. 3. Pharmacokinetics of trifluperidol.
Arzneimittelforschung. 1970 Nov;20(11):1701-5.

74:    Van Gestel S, Lewi PJ, Reyntjens A.
An automatic system for the management of drug-related literature.
Methods Inf Med. 1970 Oct;9(4):241-5.

75:    Heykants JJ, Lewi PJ, Janssen PA.
On the distribution and metabolism of neuroleptic drugs. II. Pharmacokinetics of moperone.
Arzneimittelforschung. 1970 Sep;20(9):1238-42.

76:     Lewi PJ, Niemegeers CJ, Verbruggen FJ, Braet WW, Van Riel DG, Janssen PA.
Application of on-line computer procedures to experimental control and evaluation of the effects of drugs on operant behaviour (Sidman shock-avoidance responding by rats).
Arch Int Pharmacodyn Ther. 1970 Aug;186(2):402-12.

77:    Lewi PJ, Heykants JJ, Allewijn FT, Dony JG, Janssen PA.
Distribution and metabolism of neuroleptic drugs. I. Pharmacokinetics of haloperidol.
Arzneimittelforschung. 1970 Jul;20(7):943-8.

78:    Lewi PJ, Chandler AE, van Riel DG, Somers PJ, Allewijn FT, Dony JG, Janssen PA.
Computer procedures for evaluating the results of studies on the distribution and metabolism of drugs in the body.
Arzneimittelforschung. 1970 May;20(5):684-93.

79:     Lewi PJ, Niemegeers CJ.
A systems approach to quantitative pharmacology. A review of the authors' methodology.
Eur J Pharmacol. 1970;11(3):361-70.

80:    Lewi PJ, Pinchard AG.
An automated Minnesota Multiphasic Personality Inventory test.
Acta Psychol (Amst). 1967 Nov;26(4):397-9.

81:    Lewi P, Schaper W.
Standing waves inside the heart.
Nature. 1966 Aug 27;211(52):985-6.

82:    Lewi PJ.
Forced oscillations in a Windkessel model.
Bull Math Biophys. 1965 Sep;27(3):271-80

83:    SCHAPER WK, LEWI P, JAGENEAU AH.
THE DETERMINANTS OF THE RATE OF CHANGE OF THE LEFT VENTRICULAR PRESSURE (DP/DT).
Arch Kreislaufforsch. 1965 Mar;46:27-41.

84:     LEWI P, SCHAPER W.
ON THE ELASTICITY THEORY OF HIGHLY ELASTIC BODIES. COMPARISON BETWEEN CRYSTAL ELASTICITY AND RUBBER ELASTICITY.

Z Biol. 1964 Jul;114:380-95. German.

85:     LEWI P.
AREAS UNDER THERMAL-DILUTION CURVES, ASSUMING LOG-NORMAL DISTRIBUTION.
Am J Physiol. 1964 Jul;207:144-8.

Back to Begin of Page

Back to Home Page